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SMILES: CCNC(=O)Nc1ccc(cc1)-c1nc2CN(Cc2c(n1)N1CCOCC1)c1ncccn1

InChI Key: InChIKey=ZXQOTUSTYCUIBX-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50400359   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50400359
PNG
(CHEMBL2181664)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc2CN(Cc2c(n1)N1CCOCC1)c1ncccn1
Show InChI InChI=1S/C23H26N8O2/c1-2-24-23(32)27-17-6-4-16(5-7-17)20-28-19-15-31(22-25-8-3-9-26-22)14-18(19)21(29-20)30-10-12-33-13-11-30/h3-9H,2,10-15H2,1H3,(H2,24,27,32)
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Similars
Article
PubMed
 3n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant mTOR by FRET assay

J Med Chem 55: 10958-71 (2012)


Article DOI: 10.1021/jm301389h
BindingDB Entry DOI: 10.7270/Q2125TSR
More data for this
Ligand-Target Pair