BDBM50400604 CHEMBL2203427

SMILES: CCN1CCC(Cc2ccc(nc2)C(=O)Nc2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)CC1

InChI Key: InChIKey=NCPGPVUTWKUPPM-UHFFFAOYSA-N

Data: 1 IC50  2 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50400604   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony-stimulating factor 1 receptor (c-Fms) (Mus musculus (Mouse))	BDBM50400604 (CHEMBL2203427) Show SMILES CCN1CCC(Cc2ccc(nc2)C(=O)Nc2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)CC1 Show InChI InChI=1S/C28H36N6O3/c1-5-34-14-12-19(13-15-34)16-20-6-11-23(29-18-20)26(35)30-21-7-9-22(10-8-21)31-27(36)32-25-17-24(37-33-25)28(2,3)4/h6-11,17-19H,5,12-16H2,1-4H3,(H,30,35)(H2,31,32,33,36)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	67.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of CSF1R in mouse M-NFS-60 cells assessed as inhibition of cell proliferation after 72 hrs by Celltiter-Blue assay				ACS Med Chem Lett 3: 997-1002 (2012) Article DOI: 10.1021/ml300214g BindingDB Entry DOI: 10.7270/Q22V2H9V
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50400604 (CHEMBL2203427) Show SMILES CCN1CCC(Cc2ccc(nc2)C(=O)Nc2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)CC1 Show InChI InChI=1S/C28H36N6O3/c1-5-34-14-12-19(13-15-34)16-20-6-11-23(29-18-20)26(35)30-21-7-9-22(10-8-21)31-27(36)32-25-17-24(37-33-25)28(2,3)4/h6-11,17-19H,5,12-16H2,1-4H3,(H,30,35)(H2,31,32,33,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to FLT3 expressed in HEK-293 cells after 1 hr				ACS Med Chem Lett 3: 997-1002 (2012) Article DOI: 10.1021/ml300214g BindingDB Entry DOI: 10.7270/Q22V2H9V
					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50400604 (CHEMBL2203427) Show SMILES CCN1CCC(Cc2ccc(nc2)C(=O)Nc2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)CC1 Show InChI InChI=1S/C28H36N6O3/c1-5-34-14-12-19(13-15-34)16-20-6-11-23(29-18-20)26(35)30-21-7-9-22(10-8-21)31-27(36)32-25-17-24(37-33-25)28(2,3)4/h6-11,17-19H,5,12-16H2,1-4H3,(H,30,35)(H2,31,32,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to CSF1R expressed in HEK-293 cells after 1 hr				ACS Med Chem Lett 3: 997-1002 (2012) Article DOI: 10.1021/ml300214g BindingDB Entry DOI: 10.7270/Q22V2H9V
					More data for this Ligand-Target Pair