Found 3 hits for monomerid = 50402425 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50402425
(CHEMBL2208026)Show SMILES CC(=O)Nc1ccc(cc1)-c1cc(Nc2ccc(cc2)N2CCOCC2)ncn1 Show InChI InChI=1S/C22H23N5O2/c1-16(28)25-18-4-2-17(3-5-18)21-14-22(24-15-23-21)26-19-6-8-20(9-7-19)27-10-12-29-13-11-27/h2-9,14-15H,10-13H2,1H3,(H,25,28)(H,23,24,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Exelixis
Curated by ChEMBL
| Assay Description Inhibition of JAK2 in HEL 92.1.7 cells assessed as inhibition of STAT1 phosphorylation |
Bioorg Med Chem Lett 22: 7653-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.007 BindingDB Entry DOI: 10.7270/Q2PZ59ZN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50402425
(CHEMBL2208026)Show SMILES CC(=O)Nc1ccc(cc1)-c1cc(Nc2ccc(cc2)N2CCOCC2)ncn1 Show InChI InChI=1S/C22H23N5O2/c1-16(28)25-18-4-2-17(3-5-18)21-14-22(24-15-23-21)26-19-6-8-20(9-7-19)27-10-12-29-13-11-27/h2-9,14-15H,10-13H2,1H3,(H,25,28)(H,23,24,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >980 | n/a | n/a | n/a | n/a | n/a | n/a |
Exelixis
Curated by ChEMBL
| Assay Description Inhibition of JAK2 |
Bioorg Med Chem Lett 22: 7653-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.007 BindingDB Entry DOI: 10.7270/Q2PZ59ZN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50402425
(CHEMBL2208026)Show SMILES CC(=O)Nc1ccc(cc1)-c1cc(Nc2ccc(cc2)N2CCOCC2)ncn1 Show InChI InChI=1S/C22H23N5O2/c1-16(28)25-18-4-2-17(3-5-18)21-14-22(24-15-23-21)26-19-6-8-20(9-7-19)27-10-12-29-13-11-27/h2-9,14-15H,10-13H2,1H3,(H,25,28)(H,23,24,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >980 | n/a | n/a | n/a | n/a | n/a | n/a |
Exelixis
Curated by ChEMBL
| Assay Description Inhibition of JAK3 |
Bioorg Med Chem Lett 22: 7653-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.007 BindingDB Entry DOI: 10.7270/Q2PZ59ZN |
More data for this Ligand-Target Pair | |