BDBM50402428 CHEMBL2207765

SMILES: CC(=O)Nc1ccc(cc1)-c1ccnc(Nc2cccc(NC(=O)c3c(Cl)cccc3Cl)n2)n1

InChI Key: InChIKey=HNZDEBHWPODCPN-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50402428   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50402428 (CHEMBL2207765) Show SMILES CC(=O)Nc1ccc(cc1)-c1ccnc(Nc2cccc(NC(=O)c3c(Cl)cccc3Cl)n2)n1 Show InChI InChI=1S/C24H18Cl2N6O2/c1-14(33)28-16-10-8-15(9-11-16)19-12-13-27-24(29-19)32-21-7-3-6-20(30-21)31-23(34)22-17(25)4-2-5-18(22)26/h2-13H,1H3,(H,28,33)(H2,27,29,30,31,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Exelixis Curated by ChEMBL					Assay Description Inhibition of JAK2 in HEL 92.1.7 cells assessed as inhibition of STAT1 phosphorylation				Bioorg Med Chem Lett 22: 7653-8 (2012) Article DOI: 10.1016/j.bmcl.2012.10.007 BindingDB Entry DOI: 10.7270/Q2PZ59ZN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50402428 (CHEMBL2207765) Show SMILES CC(=O)Nc1ccc(cc1)-c1ccnc(Nc2cccc(NC(=O)c3c(Cl)cccc3Cl)n2)n1 Show InChI InChI=1S/C24H18Cl2N6O2/c1-14(33)28-16-10-8-15(9-11-16)19-12-13-27-24(29-19)32-21-7-3-6-20(30-21)31-23(34)22-17(25)4-2-5-18(22)26/h2-13H,1H3,(H,28,33)(H2,27,29,30,31,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Exelixis Curated by ChEMBL					Assay Description Inhibition of JAK2				Bioorg Med Chem Lett 22: 7653-8 (2012) Article DOI: 10.1016/j.bmcl.2012.10.007 BindingDB Entry DOI: 10.7270/Q2PZ59ZN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50402428 (CHEMBL2207765) Show SMILES CC(=O)Nc1ccc(cc1)-c1ccnc(Nc2cccc(NC(=O)c3c(Cl)cccc3Cl)n2)n1 Show InChI InChI=1S/C24H18Cl2N6O2/c1-14(33)28-16-10-8-15(9-11-16)19-12-13-27-24(29-19)32-21-7-3-6-20(30-21)31-23(34)22-17(25)4-2-5-18(22)26/h2-13H,1H3,(H,28,33)(H2,27,29,30,31,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>980	n/a	n/a	n/a	n/a	n/a	n/a
Exelixis Curated by ChEMBL					Assay Description Inhibition of JAK3				Bioorg Med Chem Lett 22: 7653-8 (2012) Article DOI: 10.1016/j.bmcl.2012.10.007 BindingDB Entry DOI: 10.7270/Q2PZ59ZN
					More data for this Ligand-Target Pair