BDBM50402702 CHEMBL2207386
SMILES: CN1CCN(Cc2cccc3n(ccc23)S(=O)(=O)c2ccccc2Br)CC1
InChI Key: InChIKey=AGKMPGSBLMAGAX-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50402702 (CHEMBL2207386) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Limited Curated by ChEMBL | Assay Description Displacement of [3H]-LSD from cloned human 5HT6 receptor expressed in HEK293 cells | Bioorg Med Chem Lett 22: 7431-5 (2012) Article DOI: 10.1016/j.bmcl.2012.10.057 BindingDB Entry DOI: 10.7270/Q25140DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50402702 (CHEMBL2207386) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 135 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Limited Curated by ChEMBL | Assay Description Antagonist activity at recombinant human 5HT6 receptor expressed in CHO cells assessed as inhibition of 5HT-stimulated cAMP accumulation after 4 hrs ... | Bioorg Med Chem Lett 22: 7431-5 (2012) Article DOI: 10.1016/j.bmcl.2012.10.057 BindingDB Entry DOI: 10.7270/Q25140DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50402702 (CHEMBL2207386) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Limited Curated by ChEMBL | Assay Description Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 10 mins in presence of NADPH | Bioorg Med Chem Lett 22: 7431-5 (2012) Article DOI: 10.1016/j.bmcl.2012.10.057 BindingDB Entry DOI: 10.7270/Q25140DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50402702 (CHEMBL2207386) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Limited Curated by ChEMBL | Assay Description Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 5 mins in presence of NADPH | Bioorg Med Chem Lett 22: 7431-5 (2012) Article DOI: 10.1016/j.bmcl.2012.10.057 BindingDB Entry DOI: 10.7270/Q25140DD | |||||||||||
More data for this Ligand-Target Pair |