Found 4 hits for monomerid = 50403259 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neprilysin
(Homo sapiens (Human)) | BDBM50403259
(CHEMBL298388)Show SMILES OC(=O)CN1c2ccccc2SC[C@H](NC(=O)[C@@H](S)Cc2ccccc2)C1=O Show InChI InChI=1S/C20H20N2O4S2/c23-18(24)11-22-15-8-4-5-9-17(15)28-12-14(20(22)26)21-19(25)16(27)10-13-6-2-1-3-7-13/h1-9,14,16,27H,10-12H2,(H,21,25)(H,23,24)/t14-,16-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested in vitro for inhibition of neutral endopeptidase (NEP) |
Bioorg Med Chem Lett 4: 1789-1794 (1994)
Article DOI: 10.1016/S0960-894X(01)80372-3 BindingDB Entry DOI: 10.7270/Q22Z16PQ |
More data for this Ligand-Target Pair | |
Neutral Endopeptidase (NEP)
(Rattus norvegicus (Rat)) | BDBM50403259
(CHEMBL298388)Show SMILES OC(=O)CN1c2ccccc2SC[C@H](NC(=O)[C@@H](S)Cc2ccccc2)C1=O Show InChI InChI=1S/C20H20N2O4S2/c23-18(24)11-22-15-8-4-5-9-17(15)28-12-14(20(22)26)21-19(25)16(27)10-13-6-2-1-3-7-13/h1-9,14,16,27H,10-12H2,(H,21,25)(H,23,24)/t14-,16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of Neutral Endopeptidase isolated from rat kidney. |
Bioorg Med Chem Lett 4: 2193-2198 (1994)
Article DOI: 10.1016/S0960-894X(00)80070-0 BindingDB Entry DOI: 10.7270/Q2F47Q9D |
More data for this Ligand-Target Pair | |
Angiotensin-converting enzyme
(Rattus norvegicus) | BDBM50403259
(CHEMBL298388)Show SMILES OC(=O)CN1c2ccccc2SC[C@H](NC(=O)[C@@H](S)Cc2ccccc2)C1=O Show InChI InChI=1S/C20H20N2O4S2/c23-18(24)11-22-15-8-4-5-9-17(15)28-12-14(20(22)26)21-19(25)16(27)10-13-6-2-1-3-7-13/h1-9,14,16,27H,10-12H2,(H,21,25)(H,23,24)/t14-,16-/m0/s1 | KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of angiotensin converting enzyme isolated from rat lung. |
Bioorg Med Chem Lett 4: 2193-2198 (1994)
Article DOI: 10.1016/S0960-894X(00)80070-0 BindingDB Entry DOI: 10.7270/Q2F47Q9D |
More data for this Ligand-Target Pair | |
Angiotensin-converting enzyme
(Homo sapiens (Human)) | BDBM50403259
(CHEMBL298388)Show SMILES OC(=O)CN1c2ccccc2SC[C@H](NC(=O)[C@@H](S)Cc2ccccc2)C1=O Show InChI InChI=1S/C20H20N2O4S2/c23-18(24)11-22-15-8-4-5-9-17(15)28-12-14(20(22)26)21-19(25)16(27)10-13-6-2-1-3-7-13/h1-9,14,16,27H,10-12H2,(H,21,25)(H,23,24)/t14-,16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested in vitro for inhibition of Angiotensin converting enzyme (ACE) |
Bioorg Med Chem Lett 4: 1789-1794 (1994)
Article DOI: 10.1016/S0960-894X(01)80372-3 BindingDB Entry DOI: 10.7270/Q22Z16PQ |
More data for this Ligand-Target Pair | |