BDBM50403649 CYCLAZOSIN
SMILES: COc1cc2nc(nc(N)c2cc1OC)N1CCN([C@H]2CCCC[C@@H]12)C(=O)c1ccco1
InChI Key: InChIKey=XBRXTUGRUXGBPX-DLBZAZTESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Adrenergic receptor alpha (Homo sapiens (Human)) | BDBM50403649 (CYCLAZOSIN) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 0.135 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Camerino Curated by ChEMBL | Assay Description Displacement of [3H]prazosin from human alpha1B adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method | Bioorg Med Chem 26: 3502-3513 (2018) Article DOI: 10.1016/j.bmc.2018.05.023 BindingDB Entry DOI: 10.7270/Q2X92DS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-casein (Rattus norvegicus) | BDBM50403649 (CYCLAZOSIN) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 0.141 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Compound was tested for binding affinity against native Alpha-1B adrenergic receptor from rat liver using radioligand ([3H]prazosin) binding assay | J Med Chem 39: 4602-7 (1996) Article DOI: 10.1021/jm960510x BindingDB Entry DOI: 10.7270/Q29W0J6P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1D adrenergic receptor (Homo sapiens (Human)) | BDBM50403649 (CYCLAZOSIN) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells | J Med Chem 52: 4951-4 (2009) Article DOI: 10.1021/jm8016046 BindingDB Entry DOI: 10.7270/Q2NZ88W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor (Homo sapiens (Human)) | BDBM50403649 (CYCLAZOSIN) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 0.309 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Compound was tested for binding affinity against cloned Alpha-1B adrenergic receptor from hamster smooth muscle using radioligand ([3H]prazosin) bind... | J Med Chem 39: 4602-7 (1996) Article DOI: 10.1021/jm960510x BindingDB Entry DOI: 10.7270/Q29W0J6P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic alpha1B (Homo sapiens (Human)) | BDBM50403649 (CYCLAZOSIN) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 0.324 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells | J Med Chem 52: 4951-4 (2009) Article DOI: 10.1021/jm8016046 BindingDB Entry DOI: 10.7270/Q2NZ88W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha adrenergic receptor 1A and 1D (Rattus norvegicus (Rat)) | BDBM50403649 (CYCLAZOSIN) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 0.575 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain. | J Med Chem 39: 4602-7 (1996) Article DOI: 10.1021/jm960510x BindingDB Entry DOI: 10.7270/Q29W0J6P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor alpha (Homo sapiens (Human)) | BDBM50403649 (CYCLAZOSIN) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 0.692 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Camerino Curated by ChEMBL | Assay Description Binding affinity to human alpha1B adrenergic receptor | Bioorg Med Chem 26: 3502-3513 (2018) Article DOI: 10.1016/j.bmc.2018.05.023 BindingDB Entry DOI: 10.7270/Q2X92DS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50403649 (CYCLAZOSIN) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 0.794 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Binding affinity against native Alpha-1 adrenergic receptor from rat cerebral cortex using radioligand [3H]-prazosin binding assay | J Med Chem 39: 4602-7 (1996) Article DOI: 10.1021/jm960510x BindingDB Entry DOI: 10.7270/Q29W0J6P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50403649 (CYCLAZOSIN) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Binding affinity against native Alpha-1A adrenergic receptor from rat hippocampus pretreated with chloroethylclonidine using radioligand ([3H]prazosi... | J Med Chem 39: 4602-7 (1996) Article DOI: 10.1021/jm960510x BindingDB Entry DOI: 10.7270/Q29W0J6P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cerebral cortex alpha adrenergic receptor (CALF) | BDBM50403649 (CYCLAZOSIN) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Compound was tested for binding affinity against cloned Alpha-1A adrenergic receptor from bovine brain using radioligand ([3H]prazosin) binding assay | J Med Chem 39: 4602-7 (1996) Article DOI: 10.1021/jm960510x BindingDB Entry DOI: 10.7270/Q29W0J6P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human)) | BDBM50403649 (CYCLAZOSIN) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Camerino Curated by ChEMBL | Assay Description Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method | Bioorg Med Chem 26: 3502-3513 (2018) Article DOI: 10.1016/j.bmc.2018.05.023 BindingDB Entry DOI: 10.7270/Q2X92DS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50403649 (CYCLAZOSIN) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Displacement of [3H]prazosin from human alpha1A adrenoceptor expressed in CHO cells | J Med Chem 52: 4951-4 (2009) Article DOI: 10.1021/jm8016046 BindingDB Entry DOI: 10.7270/Q2NZ88W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50403649 (CYCLAZOSIN) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Camerino Curated by ChEMBL | Assay Description Displacement of [3H]prazosin from human alpha1A adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method | Bioorg Med Chem 26: 3502-3513 (2018) Article DOI: 10.1016/j.bmc.2018.05.023 BindingDB Entry DOI: 10.7270/Q2X92DS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50403649 (CYCLAZOSIN) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PubMed | 741 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bologna Curated by ChEMBL | Assay Description Antagonistic affinity against native rat cortex Alpha-2 adrenergic receptor | Bioorg Med Chem Lett 8: 1353-8 (1999) BindingDB Entry DOI: 10.7270/Q2V69KRR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50403649 (CYCLAZOSIN) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PubMed | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bologna Curated by ChEMBL | Assay Description Antagonistic affinity against cloned human 5-hydroxytryptamine 1A receptor | Bioorg Med Chem Lett 8: 1353-8 (1999) BindingDB Entry DOI: 10.7270/Q2V69KRR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50403649 (CYCLAZOSIN) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 1.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Binding affinity against native Alpha-2 adrenergic receptor from rat cerebral cortex using radioligand ([3H]rauwolscine) binding assay | J Med Chem 39: 4602-7 (1996) Article DOI: 10.1021/jm960510x BindingDB Entry DOI: 10.7270/Q29W0J6P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50403649 (CYCLAZOSIN) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 6.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Binding affinity against native 5-HT1A-receptors from rat hippocampus using radioligand ([3H]8-hydroxy-2-(di-n-propylamino)-tetraline) binding assay | J Med Chem 39: 4602-7 (1996) Article DOI: 10.1021/jm960510x BindingDB Entry DOI: 10.7270/Q29W0J6P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50403649 (CYCLAZOSIN) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PubMed | 8.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bologna Curated by ChEMBL | Assay Description Antagonistic affinity against rat striatum Dopamine receptor D2 | Bioorg Med Chem Lett 8: 1353-8 (1999) BindingDB Entry DOI: 10.7270/Q2V69KRR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50403649 (CYCLAZOSIN) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Compound was tested for binding affinity against native Dopamine receptor D2 from rat striatum using radioligand [3H]-spiperone) | J Med Chem 39: 4602-7 (1996) Article DOI: 10.1021/jm960510x BindingDB Entry DOI: 10.7270/Q29W0J6P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50403649 (CYCLAZOSIN) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 17.0 | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Antagonist activity against adrenergic alpha-1A receptor in rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contraction | Bioorg Med Chem 15: 2334-45 (2007) Article DOI: 10.1016/j.bmc.2007.01.028 BindingDB Entry DOI: 10.7270/Q2G16229 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha adrenergic receptor 1A and 1B (Rattus norvegicus (rat)) | BDBM50403649 (CYCLAZOSIN) | Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 0.661 | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Antagonist activity at rat Alpha-1B adrenoceptor assessed as inhibition if phenylephrine-induced contraction of spleen | J Med Chem 52: 4951-4 (2009) Article DOI: 10.1021/jm8016046 BindingDB Entry DOI: 10.7270/Q2NZ88W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1D adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50403649 (CYCLAZOSIN) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 0.617 | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta | J Med Chem 52: 4951-4 (2009) Article DOI: 10.1021/jm8016046 BindingDB Entry DOI: 10.7270/Q2NZ88W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1D adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50403649 (CYCLAZOSIN) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 53.7 | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response | Bioorg Med Chem 15: 2334-45 (2007) Article DOI: 10.1016/j.bmc.2007.01.028 BindingDB Entry DOI: 10.7270/Q2G16229 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50403649 (CYCLAZOSIN) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.23 | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Antagonist activity at rat alpha1A adrenoceptor assessed as inhibition if norepinephrine-induced contraction of vas deference | J Med Chem 52: 4951-4 (2009) Article DOI: 10.1021/jm8016046 BindingDB Entry DOI: 10.7270/Q2NZ88W5 | |||||||||||
More data for this Ligand-Target Pair |