BDBM50406795 Cozaar::LOSARTAN POTASSIUM
SMILES: CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nn[n-]n1
InChI Key: InChIKey=MDMTUGIZSFHDIC-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Angiotensin II AT1B (RAT) | BDBM50406795 (Cozaar | LOSARTAN POTASSIUM) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membra... | J Med Chem 35: 4751-63 (1993) BindingDB Entry DOI: 10.7270/Q2VH5PFJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II AT1B (RAT) | BDBM50406795 (Cozaar | LOSARTAN POTASSIUM) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article | n/a | n/a | 9.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested in vitro for the ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor) | Bioorg Med Chem Lett 6: 1469-1474 (1996) Article DOI: 10.1016/S0960-894X(96)00250-8 BindingDB Entry DOI: 10.7270/Q2SN08XQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (Homo sapiens (Human)) | BDBM50406795 (Cozaar | LOSARTAN POTASSIUM) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro binding affinity of compound against angiotensin II AT-2 receptor | Bioorg Med Chem Lett 4: 2229-2234 (1994) Article DOI: 10.1016/S0960-894X(00)80076-1 BindingDB Entry DOI: 10.7270/Q2JQ110M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (Homo sapiens (Human)) | BDBM50406795 (Cozaar | LOSARTAN POTASSIUM) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro binding affinity of compound against Angiotensin II receptor, type 1 | Bioorg Med Chem Lett 4: 2229-2234 (1994) Article DOI: 10.1016/S0960-894X(00)80076-1 BindingDB Entry DOI: 10.7270/Q2JQ110M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II AT1B (RAT) | BDBM50406795 (Cozaar | LOSARTAN POTASSIUM) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
E. Merck Curated by ChEMBL | Assay Description Binding affinity against AT1 receptor in the presence of 0.01% BSA | J Med Chem 37: 1632-45 (1994) BindingDB Entry DOI: 10.7270/Q2RR1X9M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Multidrug resistance-associated protein 4 (Homo sapiens (Human)) | BDBM50406795 (Cozaar | LOSARTAN POTASSIUM) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and... | Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II type 1a (AT-1a) receptor (Bos taurus) | BDBM50406795 (Cozaar | LOSARTAN POTASSIUM) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Chemical Industries, Ltd. Curated by ChEMBL | Assay Description Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex | J Med Chem 36: 2182-95 (1993) BindingDB Entry DOI: 10.7270/Q20Z73X8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (AT-1) type-1 (RAT) | BDBM50406795 (Cozaar | LOSARTAN POTASSIUM) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article | n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro binding affinity determined against angiotensin II AT1 receptor in rat adrenal cortex preparation | Bioorg Med Chem Lett 5: 2665-2670 (1995) Article DOI: 10.1016/0960-894X(95)00477-B BindingDB Entry DOI: 10.7270/Q2ZW1KVW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (RAT) | BDBM50406795 (Cozaar | LOSARTAN POTASSIUM) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Angiotensin II receptor antagonist activity was determined by 50% inhibition of specific binding of [3H]angiotensin II (2 nM) to rat adrenal cortical... | Citation and Details BindingDB Entry DOI: 10.7270/Q2T72KMB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Canalicular multispecific organic anion transporter 2 (Homo sapiens (Human)) | BDBM50406795 (Cozaar | LOSARTAN POTASSIUM) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ... | Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile salt export pump (Homo sapiens (Human)) | BDBM50406795 (Cozaar | LOSARTAN POTASSIUM) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 8.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ... | Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II AT2 (RAT) | BDBM50406795 (Cozaar | LOSARTAN POTASSIUM) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation | Bioorg Med Chem Lett 5: 2665-2670 (1995) Article DOI: 10.1016/0960-894X(95)00477-B BindingDB Entry DOI: 10.7270/Q2ZW1KVW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor (Cavia porcellus) | BDBM50406795 (Cozaar | LOSARTAN POTASSIUM) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
ICI Pharmaceuticals Curated by ChEMBL | Assay Description In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparation | J Med Chem 35: 4027-38 (1992) BindingDB Entry DOI: 10.7270/Q2G44P8Q | |||||||||||
More data for this Ligand-Target Pair |