BindingDB logo
myBDB logout

null

SMILES: Clc1ccc(Cc2noc(CCCc3cnc[nH]3)n2)cc1

InChI Key: InChIKey=ZCKNMEWUKBCIAP-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50409217   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50409217
PNG
(CHEMBL45056)
Show SMILES Clc1ccc(Cc2noc(CCCc3cnc[nH]3)n2)cc1
Show InChI InChI=1S/C15H15ClN4O/c16-12-6-4-11(5-7-12)8-14-19-15(21-20-14)3-1-2-13-9-17-10-18-13/h4-7,9-10H,1-3,8H2,(H,17,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
 25n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against H3 receptor in rat cerebral cortex membranes was evaluated using [3H]N-methyl-histamine as radioligand

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GF0WP5
More data for this
Ligand-Target Pair
Histamine H3 receptor


(GUINEA PIG)		BDBM50409217
PNG
(CHEMBL45056)
Show SMILES Clc1ccc(Cc2noc(CCCc3cnc[nH]3)n2)cc1
Show InChI InChI=1S/C15H15ClN4O/c16-12-6-4-11(5-7-12)8-14-19-15(21-20-14)3-1-2-13-9-17-10-18-13/h4-7,9-10H,1-3,8H2,(H,17,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/a 7.94n/an/an/an/an/a



De Novo Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortex

J Med Chem 44: 1666-74 (2001)


BindingDB Entry DOI: 10.7270/Q2WH2QP8
More data for this
Ligand-Target Pair