null

SMILES: CC[C@@H](C)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)C(C)(C)NC(=O)OC(C)(C)C)C(C)C)C(C)C)C(=O)NC(C)(C)C(=O)N[C@H]([C@H](C)OCc1ccccc1)C(=O)N[C@H](C(C)C)C(=O)NC(C)(C)C(=O)N[C@H](C(C)C)C(=O)N[C@H]([C@H](C)CC)C(=O)NC(C)(C)C(=O)OC

InChI Key: InChIKey=PCHBJOLERCSJIL-GVAMVJHNSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50410178   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50410178 (CHEMBL2096802) Show SMILES CC[C@@H](C)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)C(C)(C)NC(=O)OC(C)(C)C)C(C)C)C(C)C)C(=O)NC(C)(C)C(=O)N[C@H]([C@H](C)OCc1ccccc1)C(=O)N[C@H](C(C)C)C(=O)NC(C)(C)C(=O)N[C@H](C(C)C)C(=O)N[C@H]([C@H](C)CC)C(=O)NC(C)(C)C(=O)OC Show InChI InChI=1S/C65H111N11O15/c1-26-38(11)46(68-49(77)42(34(3)4)66-50(78)43(35(5)6)71-58(86)64(21,22)76-60(88)91-61(14,15)16)54(82)74-63(19,20)57(85)72-48(40(13)90-33-41-31-29-28-30-32-41)52(80)67-45(37(9)10)53(81)73-62(17,18)56(84)70-44(36(7)8)51(79)69-47(39(12)27-2)55(83)75-65(23,24)59(87)89-25/h28-32,34-40,42-48H,26-27,33H2,1-25H3,(H,66,78)(H,67,80)(H,68,77)(H,69,79)(H,70,84)(H,71,86)(H,72,85)(H,73,81)(H,74,82)(H,75,83)(H,76,88)/t38-,39-,40+,42-,43-,44-,45-,46-,47-,48-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporter				J Med Chem 47: 3931-3 (2004) Article DOI: 10.1021/jm049788c BindingDB Entry DOI: 10.7270/Q29Z94C2
					More data for this Ligand-Target Pair