BindingDB PrimarySearch

BDBM50411406 CHEMBL232601

SMILES: O=C(Nc1sc2N(CCCc2c1C#N)C(=O)C1CC1)c1cccc2ccccc12

InChI Key: InChIKey=KTBZRPANEUUZDW-UHFFFAOYSA-N

Data: 15 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50411406
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50411406 (CHEMBL232601) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of PLK1				Bioorg Med Chem Lett 17: 1296-301 (2007) Article DOI: 10.1016/j.bmcl.2006.12.003 BindingDB Entry DOI: 10.7270/Q2TB1840
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM50411406 (CHEMBL232601) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of human truncated JNK3				Bioorg Med Chem Lett 17: 1296-301 (2007) Article DOI: 10.1016/j.bmcl.2006.12.003 BindingDB Entry DOI: 10.7270/Q2TB1840
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50411406 (CHEMBL232601) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of Alk5				Bioorg Med Chem Lett 17: 1296-301 (2007) Article DOI: 10.1016/j.bmcl.2006.12.003 BindingDB Entry DOI: 10.7270/Q2TB1840
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50411406 (CHEMBL232601) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of VegFr2				Bioorg Med Chem Lett 17: 1296-301 (2007) Article DOI: 10.1016/j.bmcl.2006.12.003 BindingDB Entry DOI: 10.7270/Q2TB1840
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50411406 (CHEMBL232601) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 17: 1296-301 (2007) Article DOI: 10.1016/j.bmcl.2006.12.003 BindingDB Entry DOI: 10.7270/Q2TB1840
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50411406 (CHEMBL232601) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of cFms				Bioorg Med Chem Lett 17: 1296-301 (2007) Article DOI: 10.1016/j.bmcl.2006.12.003 BindingDB Entry DOI: 10.7270/Q2TB1840
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50411406 (CHEMBL232601) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of human recombinant full length JNK1alpha1				Bioorg Med Chem Lett 17: 1296-301 (2007) Article DOI: 10.1016/j.bmcl.2006.12.003 BindingDB Entry DOI: 10.7270/Q2TB1840
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50411406 (CHEMBL232601) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of ErbB2				Bioorg Med Chem Lett 17: 1296-301 (2007) Article DOI: 10.1016/j.bmcl.2006.12.003 BindingDB Entry DOI: 10.7270/Q2TB1840
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50411406 (CHEMBL232601) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of human JNK2alpha2				Bioorg Med Chem Lett 17: 1296-301 (2007) Article DOI: 10.1016/j.bmcl.2006.12.003 BindingDB Entry DOI: 10.7270/Q2TB1840
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50411406 (CHEMBL232601) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.58E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of mitogen-activated protein kinase p38alpha				Bioorg Med Chem Lett 17: 1296-301 (2007) Article DOI: 10.1016/j.bmcl.2006.12.003 BindingDB Entry DOI: 10.7270/Q2TB1840
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM50411406 (CHEMBL232601) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of human recombinant full length ERK2				Bioorg Med Chem Lett 17: 1296-301 (2007) Article DOI: 10.1016/j.bmcl.2006.12.003 BindingDB Entry DOI: 10.7270/Q2TB1840
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50411406 (CHEMBL232601) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of EGFR				Bioorg Med Chem Lett 17: 1296-301 (2007) Article DOI: 10.1016/j.bmcl.2006.12.003 BindingDB Entry DOI: 10.7270/Q2TB1840
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50411406 (CHEMBL232601) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of Tie2				Bioorg Med Chem Lett 17: 1296-301 (2007) Article DOI: 10.1016/j.bmcl.2006.12.003 BindingDB Entry DOI: 10.7270/Q2TB1840
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50411406 (CHEMBL232601) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of GSK3-beta				Bioorg Med Chem Lett 17: 1296-301 (2007) Article DOI: 10.1016/j.bmcl.2006.12.003 BindingDB Entry DOI: 10.7270/Q2TB1840
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50411406 (CHEMBL232601) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of Src				Bioorg Med Chem Lett 17: 1296-301 (2007) Article DOI: 10.1016/j.bmcl.2006.12.003 BindingDB Entry DOI: 10.7270/Q2TB1840
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair