BDBM50412224 CHEMBL479591
SMILES: Cc1cc(nn1Cc1cc(Cl)ccc1OCc1ccccc1)C(=O)Nc1ccc(CN2CCOCC2)cc1
InChI Key: InChIKey=DRXAZGSQFACNDY-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin E2 receptor EP1 subtype (EP1) (Homo sapiens (Human)) | BDBM50412224 (CHEMBL479591) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 79.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assay | Bioorg Med Chem Lett 18: 4027-32 (2008) Article DOI: 10.1016/j.bmcl.2008.05.118 BindingDB Entry DOI: 10.7270/Q2NC62F7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP1 subtype (EP1) (Homo sapiens (Human)) | BDBM50412224 (CHEMBL479591) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells | Bioorg Med Chem Lett 18: 4027-32 (2008) Article DOI: 10.1016/j.bmcl.2008.05.118 BindingDB Entry DOI: 10.7270/Q2NC62F7 | |||||||||||
More data for this Ligand-Target Pair |