BindingDB logo
myBDB logout

null

SMILES: NC(NC(=O)CC(c1nccn1Cc1ccccc1)c1ccc(F)c(F)c1)=NCCCc1cnc[nH]1

InChI Key: InChIKey=HDDMVAQKQDEVQJ-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50413177   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50413177
PNG
(CHEMBL513039)
Show SMILES NC(NC(=O)CC(c1nccn1Cc1ccccc1)c1ccc(F)c(F)c1)=NCCCc1cnc[nH]1 |w:27.30|
Show InChI InChI=1S/C26H27F2N7O/c27-22-9-8-19(13-23(22)28)21(25-31-11-12-35(25)16-18-5-2-1-3-6-18)14-24(36)34-26(29)32-10-4-7-20-15-30-17-33-20/h1-3,5-6,8-9,11-13,15,17,21H,4,7,10,14,16H2,(H,30,33)(H3,29,32,34,36)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 398n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity

J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair