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BDBM50414840 CHEMBL576756

SMILES: CNc1ncc2C(=O)CC(CN3CCC(CC3)c3noc4cc(F)ccc34)Cc2n1

InChI Key: InChIKey=GFDZRHZKBRJIGS-UHFFFAOYSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50414840   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50414840
PNG
(CHEMBL576756)
Show SMILES CNc1ncc2C(=O)CC(CN3CCC(CC3)c3noc4cc(F)ccc34)Cc2n1
Show InChI InChI=1S/C22H24FN5O2/c1-24-22-25-11-17-18(26-22)8-13(9-19(17)29)12-28-6-4-14(5-7-28)21-16-3-2-15(23)10-20(16)30-27-21/h2-3,10-11,13-14H,4-9,12H2,1H3,(H,24,25,26)
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2.40n/an/an/an/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human cloned 5HT2A receptor


Bioorg Med Chem Lett 19: 6059-62 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.041
BindingDB Entry DOI: 10.7270/Q2M046P5
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50414840
PNG
(CHEMBL576756)
Show SMILES CNc1ncc2C(=O)CC(CN3CCC(CC3)c3noc4cc(F)ccc34)Cc2n1
Show InChI InChI=1S/C22H24FN5O2/c1-24-22-25-11-17-18(26-22)8-13(9-19(17)29)12-28-6-4-14(5-7-28)21-16-3-2-15(23)10-20(16)30-27-21/h2-3,10-11,13-14H,4-9,12H2,1H3,(H,24,25,26)
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PC sid
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42.7n/an/an/an/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor


Bioorg Med Chem Lett 19: 6059-62 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.041
BindingDB Entry DOI: 10.7270/Q2M046P5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50414840
PNG
(CHEMBL576756)
Show SMILES CNc1ncc2C(=O)CC(CN3CCC(CC3)c3noc4cc(F)ccc34)Cc2n1
Show InChI InChI=1S/C22H24FN5O2/c1-24-22-25-11-17-18(26-22)8-13(9-19(17)29)12-28-6-4-14(5-7-28)21-16-3-2-15(23)10-20(16)30-27-21/h2-3,10-11,13-14H,4-9,12H2,1H3,(H,24,25,26)
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49.0n/an/an/an/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D2 receptor


Bioorg Med Chem Lett 19: 6059-62 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.041
BindingDB Entry DOI: 10.7270/Q2M046P5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50414840
PNG
(CHEMBL576756)
Show SMILES CNc1ncc2C(=O)CC(CN3CCC(CC3)c3noc4cc(F)ccc34)Cc2n1
Show InChI InChI=1S/C22H24FN5O2/c1-24-22-25-11-17-18(26-22)8-13(9-19(17)29)12-28-6-4-14(5-7-28)21-16-3-2-15(23)10-20(16)30-27-21/h2-3,10-11,13-14H,4-9,12H2,1H3,(H,24,25,26)
UniProtKB/SwissProt

antibodypedia
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PC sid
UniChem
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200n/an/an/an/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor


Bioorg Med Chem Lett 19: 6059-62 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.041
BindingDB Entry DOI: 10.7270/Q2M046P5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50414840
PNG
(CHEMBL576756)
Show SMILES CNc1ncc2C(=O)CC(CN3CCC(CC3)c3noc4cc(F)ccc34)Cc2n1
Show InChI InChI=1S/C22H24FN5O2/c1-24-22-25-11-17-18(26-22)8-13(9-19(17)29)12-28-6-4-14(5-7-28)21-16-3-2-15(23)10-20(16)30-27-21/h2-3,10-11,13-14H,4-9,12H2,1H3,(H,24,25,26)
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UniChem
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from human 5HT2C receptor


Bioorg Med Chem Lett 19: 6059-62 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.041
BindingDB Entry DOI: 10.7270/Q2M046P5
More data for this
Ligand-Target Pair