BDBM50414870 CHEMBL566756

SMILES: COc1cc2CCCc3c(NCc4c(Cl)cccc4Cl)[nH]nc3-c2cc1OC

InChI Key: InChIKey=RIAKILITLYSECT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50414870   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 2-alpha kinase 1 (Homo sapiens (Human))	BDBM50414870 (CHEMBL566756) Show SMILES COc1cc2CCCc3c(NCc4c(Cl)cccc4Cl)[nH]nc3-c2cc1OC Show InChI InChI=1S/C21H21Cl2N3O2/c1-27-18-9-12-5-3-6-13-20(14(12)10-19(18)28-2)25-26-21(13)24-11-15-16(22)7-4-8-17(15)23/h4,7-10H,3,5-6,11H2,1-2H3,(H2,24,25,26)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of human HRI kinase				Bioorg Med Chem Lett 19: 6548-51 (2009) Article DOI: 10.1016/j.bmcl.2009.10.033 BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
					More data for this Ligand-Target Pair