BDBM50414893 CHEMBL578426

SMILES: COc1cc2Cc3c(NCc4c(C)cccc4C)[nH]nc3-c2cc1OC

InChI Key: InChIKey=GZUVCNPDJISLKF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50414893   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 2-alpha kinase 1 (Homo sapiens (Human))	BDBM50414893 (CHEMBL578426) Show SMILES COc1cc2Cc3c(NCc4c(C)cccc4C)[nH]nc3-c2cc1OC Show InChI InChI=1S/C21H23N3O2/c1-12-6-5-7-13(2)17(12)11-22-21-16-8-14-9-18(25-3)19(26-4)10-15(14)20(16)23-24-21/h5-7,9-10H,8,11H2,1-4H3,(H2,22,23,24)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.94	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of human HRI kinase				Bioorg Med Chem Lett 19: 6548-51 (2009) Article DOI: 10.1016/j.bmcl.2009.10.033 BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
					More data for this Ligand-Target Pair