BDBM50416603 CHEMBL1222883
SMILES: CN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F
InChI Key: InChIKey=BJEMSIVBBUBXMZ-JTQLQIEISA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM50416603 (CHEMBL1222883) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Competitive displacement of [11C]GSK1482160 from human recombinant P2X7 receptor expressed in HEK293 cell membranes incubated for 30 mins by scintill... | Bioorg Med Chem Lett 29: 1476-1480 (2019) Article DOI: 10.1016/j.bmcl.2019.04.018 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM50416603 (CHEMBL1222883) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille Curated by ChEMBL | Assay Description Displacement of [3H]-A804598 from human P2X7 expressed in human HEK293 cell membrane incubated for 1 hr by microplate scintillation counting method | J Med Chem 63: 2074-2094 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat)) | BDBM50416603 (CHEMBL1222883) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of rat P2X7 receptor by ethidium bromide release assay | Bioorg Med Chem Lett 20: 5080-4 (2010) Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM50416603 (CHEMBL1222883) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay | Bioorg Med Chem Lett 20: 6370-4 (2010) Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat)) | BDBM50416603 (CHEMBL1222883) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Antagonist activity at rat recombinant P2X7 receptor | Bioorg Med Chem Lett 20: 6370-4 (2010) Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM50416603 (CHEMBL1222883) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Displacement of [11C]GSK1482160 from human recombinant P2X7 receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counti... | Bioorg Med Chem Lett 29: 1476-1480 (2019) Article DOI: 10.1016/j.bmcl.2019.04.018 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM50416603 (CHEMBL1222883) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 332 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille Curated by ChEMBL | Assay Description Displacement of [3H]-A804598 from human P2X7 expressed in human HEK293 cell membrane incubated for 1 hr by microplate scintillation counting method | J Med Chem 63: 2074-2094 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM50416603 (CHEMBL1222883) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille Curated by ChEMBL | Assay Description Inhibition of human P2X7 expressed in human HEK293 cells assessed as reduction in BzATP-stimulated TO-PRO-3 incorporation preincubated with compound ... | J Med Chem 63: 2074-2094 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM50416603 (CHEMBL1222883) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay | Bioorg Med Chem Lett 20: 5080-4 (2010) Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T | |||||||||||
More data for this Ligand-Target Pair |