BDBM50417676 CHEMBL1643363

SMILES: Nc1nccc2cc(CNCCc3cccc(c3)C(F)(F)F)ccc12

InChI Key: InChIKey=FHGICQLRHVZVCW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50417676   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417676 (CHEMBL1643363) Show SMILES Nc1nccc2cc(CNCCc3cccc(c3)C(F)(F)F)ccc12 Show InChI InChI=1S/C19H18F3N3/c20-19(21,22)16-3-1-2-13(11-16)6-8-24-12-14-4-5-17-15(10-14)7-9-25-18(17)23/h1-5,7,9-11,24H,6,8,12H2,(H2,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
					More data for this Ligand-Target Pair