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SMILES: Cc1cc(nc(N)n1)-c1ccc2c(N)n[nH]c2c1

InChI Key: InChIKey=JZOJBOMGNJTZMY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50418259   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50418259 (CHEMBL1765756) Show SMILES Cc1cc(nc(N)n1)-c1ccc2c(N)n[nH]c2c1 Show InChI InChI=1S/C12H12N6/c1-6-4-9(16-12(14)15-6)7-2-3-8-10(5-7)17-18-11(8)13/h2-5H,1H3,(H3,13,17,18)(H2,14,15,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of ROCK1				J Med Chem 54: 1871-95 (2011) Article DOI: 10.1021/jm101527u BindingDB Entry DOI: 10.7270/Q2HQ406Q
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM50418259 (CHEMBL1765756) Show SMILES Cc1cc(nc(N)n1)-c1ccc2c(N)n[nH]c2c1 Show InChI InChI=1S/C12H12N6/c1-6-4-9(16-12(14)15-6)7-2-3-8-10(5-7)17-18-11(8)13/h2-5H,1H3,(H3,13,17,18)(H2,14,15,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of PDK1-mediated AKT phosphorylation at Thr308 residue in human PC3 cells by ELISA				J Med Chem 54: 1871-95 (2011) Article DOI: 10.1021/jm101527u BindingDB Entry DOI: 10.7270/Q2HQ406Q
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50418259 (CHEMBL1765756) Show SMILES Cc1cc(nc(N)n1)-c1ccc2c(N)n[nH]c2c1 Show InChI InChI=1S/C12H12N6/c1-6-4-9(16-12(14)15-6)7-2-3-8-10(5-7)17-18-11(8)13/h2-5H,1H3,(H3,13,17,18)(H2,14,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of ALK5				J Med Chem 54: 1871-95 (2011) Article DOI: 10.1021/jm101527u BindingDB Entry DOI: 10.7270/Q2HQ406Q
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50418259 (CHEMBL1765756) Show SMILES Cc1cc(nc(N)n1)-c1ccc2c(N)n[nH]c2c1 Show InChI InChI=1S/C12H12N6/c1-6-4-9(16-12(14)15-6)7-2-3-8-10(5-7)17-18-11(8)13/h2-5H,1H3,(H3,13,17,18)(H2,14,15,16)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of aurora B				J Med Chem 54: 1871-95 (2011) Article DOI: 10.1021/jm101527u BindingDB Entry DOI: 10.7270/Q2HQ406Q
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50418259 (CHEMBL1765756) Show SMILES Cc1cc(nc(N)n1)-c1ccc2c(N)n[nH]c2c1 Show InChI InChI=1S/C12H12N6/c1-6-4-9(16-12(14)15-6)7-2-3-8-10(5-7)17-18-11(8)13/h2-5H,1H3,(H3,13,17,18)(H2,14,15,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of aurora A				J Med Chem 54: 1871-95 (2011) Article DOI: 10.1021/jm101527u BindingDB Entry DOI: 10.7270/Q2HQ406Q
					More data for this Ligand-Target Pair