BDBM50418605 CHEMBL1784171

SMILES: Cc1c(F)cc(cc1-c1ccc(cc1)C(=O)NCC(C)(C)O)C(=O)NC1CC1

InChI Key: InChIKey=OLVRNGODZLMUKV-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50418605   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50418605 (CHEMBL1784171) Show SMILES Cc1c(F)cc(cc1-c1ccc(cc1)C(=O)NCC(C)(C)O)C(=O)NC1CC1 Show InChI InChI=1S/C22H25FN2O3/c1-13-18(10-16(11-19(13)23)21(27)25-17-8-9-17)14-4-6-15(7-5-14)20(26)24-12-22(2,3)28/h4-7,10-11,17,28H,8-9,12H2,1-3H3,(H,24,26)(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of GST-tagged p38alpha by fluorescence polarization method				J Med Chem 52: 6257-69 (2009) Article DOI: 10.1021/jm9004779 BindingDB Entry DOI: 10.7270/Q2J967NC
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50418605 (CHEMBL1784171) Show SMILES Cc1c(F)cc(cc1-c1ccc(cc1)C(=O)NCC(C)(C)O)C(=O)NC1CC1 Show InChI InChI=1S/C22H25FN2O3/c1-13-18(10-16(11-19(13)23)21(27)25-17-8-9-17)14-4-6-15(7-5-14)20(26)24-12-22(2,3)28/h4-7,10-11,17,28H,8-9,12H2,1-3H3,(H,24,26)(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	79.4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of p38alpha-dependent TNFalpha production in human whole blood preincubated for 1 hr before LPS challenge by ELISA				J Med Chem 52: 6257-69 (2009) Article DOI: 10.1021/jm9004779 BindingDB Entry DOI: 10.7270/Q2J967NC
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50418605 (CHEMBL1784171) Show SMILES Cc1c(F)cc(cc1-c1ccc(cc1)C(=O)NCC(C)(C)O)C(=O)NC1CC1 Show InChI InChI=1S/C22H25FN2O3/c1-13-18(10-16(11-19(13)23)21(27)25-17-8-9-17)14-4-6-15(7-5-14)20(26)24-12-22(2,3)28/h4-7,10-11,17,28H,8-9,12H2,1-3H3,(H,24,26)(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.58E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human CYP2C9 expressed in Escherichia coli by fluorimetric assay				J Med Chem 52: 6257-69 (2009) Article DOI: 10.1021/jm9004779 BindingDB Entry DOI: 10.7270/Q2J967NC
					More data for this Ligand-Target Pair