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BDBM50419058 CHEMBL1823670

SMILES: COc1ccc(cc1)C(=O)NCC1(Cc2ccccc2C1)N1CCN(C)CC1

InChI Key: InChIKey=CWDHNRALFIFGHZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50419058   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4


(Homo sapiens (Human))
BDBM50419058
PNG
(CHEMBL1823670)
Show SMILES COc1ccc(cc1)C(=O)NCC1(Cc2ccccc2C1)N1CCN(C)CC1
Show InChI InChI=1S/C23H29N3O2/c1-25-11-13-26(14-12-25)23(15-19-5-3-4-6-20(19)16-23)17-24-22(27)18-7-9-21(28-2)10-8-18/h3-10H,11-17H2,1-2H3,(H,24,27)
PDB
MMDB

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B.MOAD
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.00E+5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Bioorg Med Chem Lett 21: 5197-201 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens (Human))
BDBM50419058
PNG
(CHEMBL1823670)
Show SMILES COc1ccc(cc1)C(=O)NCC1(Cc2ccccc2C1)N1CCN(C)CC1
Show InChI InChI=1S/C23H29N3O2/c1-25-11-13-26(14-12-25)23(15-19-5-3-4-6-20(19)16-23)17-24-22(27)18-7-9-21(28-2)10-8-18/h3-10H,11-17H2,1-2H3,(H,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Bioorg Med Chem Lett 21: 5197-201 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP
More data for this
Ligand-Target Pair