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BDBM50419083 CHEMBL1823882

SMILES: CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCNCC1

InChI Key: InChIKey=YFQFHHCYQKYDBC-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50419083   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4


(Homo sapiens)
BDBM50419083
PNG
(CHEMBL1823882)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCNCC1
Show InChI InChI=1S/C20H31N3O2/c1-2-25-18-9-5-4-8-17(18)19(24)22-16-20(10-6-3-7-11-20)23-14-12-21-13-15-23/h4-5,8-9,21H,2-3,6-7,10-16H2,1H3,(H,22,24)
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PC cid
PC sid
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Article
PubMed
n/an/a 3.98E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Bioorg Med Chem Lett 21: 5197-201 (2011)

More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


(Homo sapiens)
BDBM50419083
PNG
(CHEMBL1823882)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCNCC1
Show InChI InChI=1S/C20H31N3O2/c1-2-25-18-9-5-4-8-17(18)19(24)22-16-20(10-6-3-7-11-20)23-14-12-21-13-15-23/h4-5,8-9,21H,2-3,6-7,10-16H2,1H3,(H,22,24)
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PubMed
n/an/a 5.01E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN2 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Bioorg Med Chem Lett 21: 5197-201 (2011)

More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419083
PNG
(CHEMBL1823882)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCNCC1
Show InChI InChI=1S/C20H31N3O2/c1-2-25-18-9-5-4-8-17(18)19(24)22-16-20(10-6-3-7-11-20)23-14-12-21-13-15-23/h4-5,8-9,21H,2-3,6-7,10-16H2,1H3,(H,22,24)
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PubMed
n/an/a 398n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Bioorg Med Chem Lett 21: 5197-201 (2011)

More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3


(Homo sapiens)
BDBM50419083
PNG
(CHEMBL1823882)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCNCC1
Show InChI InChI=1S/C20H31N3O2/c1-2-25-18-9-5-4-8-17(18)19(24)22-16-20(10-6-3-7-11-20)23-14-12-21-13-15-23/h4-5,8-9,21H,2-3,6-7,10-16H2,1H3,(H,22,24)
PDB

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KEGG

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 3.16E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN3 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Bioorg Med Chem Lett 21: 5197-201 (2011)

More data for this
Ligand-Target Pair