BDBM50420276 CHEMBL2089211
SMILES: COC(=O)C(N1C(c2ccc(cc2)C(F)(F)F)C(=S)Nc2cc(Cl)ccc2C1=O)c1ccc(Cl)cc1
InChI Key: InChIKey=NLDNWZLFIYLVPW-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM50420276 (CHEMBL2089211) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 518 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay | Eur J Med Chem 56: 10-16 (2012) Article DOI: 10.1016/j.ejmech.2012.08.003 BindingDB Entry DOI: 10.7270/Q2K938SR | |||||||||||
More data for this Ligand-Target Pair |