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SMILES: Cc1cc(Nc2ccnc(NCc3cc(C)no3)n2)[nH]n1

InChI Key: InChIKey=TWJNKGRJIMBKFD-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50420962   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50420962 (CHEMBL2088098) Show SMILES Cc1cc(Nc2ccnc(NCc3cc(C)no3)n2)[nH]n1 Show InChI InChI=1S/C13H15N7O/c1-8-6-12(19-18-8)16-11-3-4-14-13(17-11)15-7-10-5-9(2)20-21-10/h3-6H,7H2,1-2H3,(H3,14,15,16,17,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant N terminal His6-tagged human IGF1R (959 to end) expressed in baculovirus infected Sf21 cells after 80 mins by caliper mobil...				J Med Chem 55: 5003-12 (2012) Article DOI: 10.1021/jm3004043 BindingDB Entry DOI: 10.7270/Q25X2B62
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50420962 (CHEMBL2088098) Show SMILES Cc1cc(Nc2ccnc(NCc3cc(C)no3)n2)[nH]n1 Show InChI InChI=1S/C13H15N7O/c1-8-6-12(19-18-8)16-11-3-4-14-13(17-11)15-7-10-5-9(2)20-21-10/h3-6H,7H2,1-2H3,(H3,14,15,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	79.4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili...				J Med Chem 55: 5003-12 (2012) Article DOI: 10.1021/jm3004043 BindingDB Entry DOI: 10.7270/Q25X2B62
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50420962 (CHEMBL2088098) Show SMILES Cc1cc(Nc2ccnc(NCc3cc(C)no3)n2)[nH]n1 Show InChI InChI=1S/C13H15N7O/c1-8-6-12(19-18-8)16-11-3-4-14-13(17-11)15-7-10-5-9(2)20-21-10/h3-6H,7H2,1-2H3,(H3,14,15,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant N terminal GST-tagged human KDR (805 to 1356) expressed in baculovirus infected Sf9 cells after 90 mins by caliper mobility...				J Med Chem 55: 5003-12 (2012) Article DOI: 10.1021/jm3004043 BindingDB Entry DOI: 10.7270/Q25X2B62
					More data for this Ligand-Target Pair