BDBM50421840 MDL-18962::PLOMESTANE
SMILES: C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34CC#C)[C@@H]1CCC2=O
InChI Key: InChIKey=JKPDEYAOCSQBSZ-OEUJLIAZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 19A1 (Homo sapiens (Human)) | BDBM50421840 (MDL-18962 | PLOMESTANE) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation Curated by ChEMBL | Assay Description In vitro inhibition of Cytochrome P450 19A1 | J Med Chem 32: 2231-9 (1989) BindingDB Entry DOI: 10.7270/Q2Q52Q60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 19A1 (Homo sapiens (Human)) | BDBM50421840 (MDL-18962 | PLOMESTANE) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Curated by ChEMBL | Assay Description Binding affinity(KI) for formation of reversible enzyme-ligand complex with human placental aromatase (PL2) | J Med Chem 32: 203-13 (1989) BindingDB Entry DOI: 10.7270/Q2736RHX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 19A1 (Homo sapiens (Human)) | BDBM50421840 (MDL-18962 | PLOMESTANE) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Binding affinity for human placental microsome Cytochrome P450 19A1 by nonlinear regression analysis | J Med Chem 40: 3263-70 (1997) Article DOI: 10.1021/jm970325z BindingDB Entry DOI: 10.7270/Q23J3C33 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 19A1 (Homo sapiens (Human)) | BDBM50421840 (MDL-18962 | PLOMESTANE) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of human placental microsome Cytochrome P450 19A1 | J Med Chem 40: 3263-70 (1997) Article DOI: 10.1021/jm970325z BindingDB Entry DOI: 10.7270/Q23J3C33 | |||||||||||
More data for this Ligand-Target Pair |