Found 4 hits for monomerid = 50423191 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50423191
(CHEMBL234988)Show SMILES Nc1c(cnn1-c1ccccc1)C(=O)NCC(O)(CC1(CCC1)c1cc(F)ccc1Cl)C(F)(F)F Show InChI InChI=1S/C24H23ClF4N4O2/c25-19-8-7-15(26)11-18(19)22(9-4-10-22)13-23(35,24(27,28)29)14-31-21(34)17-12-32-33(20(17)30)16-5-2-1-3-6-16/h1-3,5-8,11-12,35H,4,9-10,13-14,30H2,(H,31,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay |
Bioorg Med Chem Lett 17: 4737-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.066
BindingDB Entry DOI: 10.7270/Q2KD206G |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50423191
(CHEMBL234988)Show SMILES Nc1c(cnn1-c1ccccc1)C(=O)NCC(O)(CC1(CCC1)c1cc(F)ccc1Cl)C(F)(F)F Show InChI InChI=1S/C24H23ClF4N4O2/c25-19-8-7-15(26)11-18(19)22(9-4-10-22)13-23(35,24(27,28)29)14-31-21(34)17-12-32-33(20(17)30)16-5-2-1-3-6-16/h1-3,5-8,11-12,35H,4,9-10,13-14,30H2,(H,31,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Binding affinity to glucocorticoid receptor |
Bioorg Med Chem Lett 17: 4737-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.066
BindingDB Entry DOI: 10.7270/Q2KD206G |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50423191
(CHEMBL234988)Show SMILES Nc1c(cnn1-c1ccccc1)C(=O)NCC(O)(CC1(CCC1)c1cc(F)ccc1Cl)C(F)(F)F Show InChI InChI=1S/C24H23ClF4N4O2/c25-19-8-7-15(26)11-18(19)22(9-4-10-22)13-23(35,24(27,28)29)14-31-21(34)17-12-32-33(20(17)30)16-5-2-1-3-6-16/h1-3,5-8,11-12,35H,4,9-10,13-14,30H2,(H,31,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Binding affinity to glucocorticoid receptor |
Bioorg Med Chem Lett 17: 4737-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.066
BindingDB Entry DOI: 10.7270/Q2KD206G |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50423191
(CHEMBL234988)Show SMILES Nc1c(cnn1-c1ccccc1)C(=O)NCC(O)(CC1(CCC1)c1cc(F)ccc1Cl)C(F)(F)F Show InChI InChI=1S/C24H23ClF4N4O2/c25-19-8-7-15(26)11-18(19)22(9-4-10-22)13-23(35,24(27,28)29)14-31-21(34)17-12-32-33(20(17)30)16-5-2-1-3-6-16/h1-3,5-8,11-12,35H,4,9-10,13-14,30H2,(H,31,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay |
Bioorg Med Chem Lett 17: 4737-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.066
BindingDB Entry DOI: 10.7270/Q2KD206G |
More data for this
Ligand-Target Pair | |
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