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SMILES: Cc1cc(CNC(=O)c2sc3nc(C)c(Cl)c(C)c3c2N)ccn1

InChI Key: InChIKey=JXTBOJKQARYDRS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50423965   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))		BDBM50423965
PNG
(CHEMBL2313379)
Show SMILES Cc1cc(CNC(=O)c2sc3nc(C)c(Cl)c(C)c3c2N)ccn1
Show InChI InChI=1S/C17H17ClN4OS/c1-8-6-11(4-5-20-8)7-21-16(23)15-14(19)12-9(2)13(18)10(3)22-17(12)24-15/h4-6H,7,19H2,1-3H3,(H,21,23)
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Article
PubMed
n/an/an/an/a 61n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated...

Bioorg Med Chem Lett 23: 346-50 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.073
BindingDB Entry DOI: 10.7270/Q2N29Z8S
More data for this
Ligand-Target Pair