BDBM50425147 CHEMBL2313567
SMILES: OC(=O)C1CCN(Cc2coc3cc(Oc4nc5ncccc5s4)ccc23)CC1
InChI Key: InChIKey=QLODKRVWQXTRHR-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Leukotriene A4 hydrolase (Homo sapiens (Human)) | BDBM50425147 (CHEMBL2313567) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development, LLC Curated by ChEMBL | Assay Description Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after... | Bioorg Med Chem Lett 23: 811-5 (2013) Article DOI: 10.1016/j.bmcl.2012.11.074 BindingDB Entry DOI: 10.7270/Q27H1KW1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leukotriene A4 hydrolase (Mus musculus) | BDBM50425147 (CHEMBL2313567) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development, LLC Curated by ChEMBL | Assay Description Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc... | Bioorg Med Chem Lett 23: 811-5 (2013) Article DOI: 10.1016/j.bmcl.2012.11.074 BindingDB Entry DOI: 10.7270/Q27H1KW1 | |||||||||||
More data for this Ligand-Target Pair |