BDBM50426536 CHEMBL2323946

SMILES: CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(CC1)c1ccc(cc1)C1CCCCC1

InChI Key: InChIKey=QKLUZQVEUCSWEW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50426536   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (TRPV4) (Homo sapiens (Human))	BDBM50426536 (CHEMBL2323946) Show SMILES CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(CC1)c1ccc(cc1)C1CCCCC1 Show InChI InChI=1S/C30H39Cl2N5O/c1-19(2)33-30-34-28-25(18-24(31)27(32)26(28)29(38)35(3)4)37(30)23-14-16-36(17-15-23)22-12-10-21(11-13-22)20-8-6-5-7-9-20/h10-13,18-20,23H,5-9,14-17H2,1-4H3,(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV4 expressed in BacMam virus infected HEK MSRII cells assessed as inhibition of GSK1016790A-induced calci...				ACS Med Chem Lett 4: 293-6 (2013) Article DOI: 10.1021/ml300449k BindingDB Entry DOI: 10.7270/Q2VT1TDB
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