BDBM50426547 CHEMBL2323957

SMILES: COc1cccc-2c1Cc1c(Nc3ccc4OCCOc4c3)[nH]nc-21

InChI Key: InChIKey=PAVLSHIVDAAQRY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50426547   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50426547 (CHEMBL2323957) Show SMILES COc1cccc-2c1Cc1c(Nc3ccc4OCCOc4c3)[nH]nc-21 Show InChI InChI=1S/C19H17N3O3/c1-23-15-4-2-3-12-13(15)10-14-18(12)21-22-19(14)20-11-5-6-16-17(9-11)25-8-7-24-16/h2-6,9H,7-8,10H2,1H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
					More data for this Ligand-Target Pair