BDBM50426549 CHEMBL2323955

SMILES: C1Oc2ccc(Nc3[nH]nc-4c3Cc3ccccc-43)cc2O1

InChI Key: InChIKey=PCDNKCLEZUFGIW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50426549   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50426549 (CHEMBL2323955) Show SMILES C1Oc2ccc(Nc3[nH]nc-4c3Cc3ccccc-43)cc2O1 Show InChI InChI=1S/C17H13N3O2/c1-2-4-12-10(3-1)7-13-16(12)19-20-17(13)18-11-5-6-14-15(8-11)22-9-21-14/h1-6,8H,7,9H2,(H2,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
					More data for this Ligand-Target Pair