BindingDB PrimarySearch

BDBM50427138 CHEMBL2323775::MK-8033

SMILES: Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCc4ccccn4)cc3c(=O)c2c1

InChI Key: InChIKey=VMJFTOSOFDEKTM-UHFFFAOYSA-N

Data: 9 IC50 3 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50427138
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Ferrochelatase R115L (FECH) (Homo sapiens (Human))	BDBM50427138 (CHEMBL2323775 \| MK-8033) Show SMILES Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a
Technical University of Munich					Assay Description Briefly, 5 mg of a protein mixture of the four cell lines or a single cell line were incubated with compound dilution series in DMSO (3 nM, 10 nM, 30...				ACS Chem Biol 11: 1245-54 (2016) Article DOI: 10.1021/acschembio.5b01063 BindingDB Entry DOI: 10.7270/Q2FB51R8
Technical University of Munich					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427138 (CHEMBL2323775 \| MK-8033) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	582	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin) expressed in human GTL16 cells assessed as inhibition of cell proliferation				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
Merck& Co., Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427138 (CHEMBL2323775 \| MK-8033) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of HGF-stimulated c-MET (unknown origin) autophosphorylation at tyrosine 1349 expressed in human GTL16 cells after 2 hrs by Western blotti...				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
Merck& Co., Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50427138 (CHEMBL2323775 \| MK-8033) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of RON (unknown origin) by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
Merck& Co., Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427138 (CHEMBL2323775 \| MK-8033) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET activation (unknown origin) expressed in human HCT116 cells				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
Merck& Co., Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50427138 (CHEMBL2323775 \| MK-8033) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of RON (unknown origin)				Eur J Med Chem 163: 413-427 (2019) Article DOI: 10.1016/j.ejmech.2018.11.072
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427138 (CHEMBL2323775 \| MK-8033) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Binding affinity to phosphorylated c-MET kinase domain (unknown origin)				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
Merck& Co., Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50427138 (CHEMBL2323775 \| MK-8033) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.62E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of CYP2D6 (unknown origin)				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
Merck& Co., Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50427138 (CHEMBL2323775 \| MK-8033) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.47E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of CYP2C9 (unknown origin)				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
Merck& Co., Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50427138 (CHEMBL2323775 \| MK-8033) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate by LC-MS-MS analysis				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
Merck& Co., Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427138 (CHEMBL2323775 \| MK-8033) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
Merck& Co., Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50427138 (CHEMBL2323775 \| MK-8033) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Binding affinity to unphosphorylated c-MET kinase domain (unknown origin)				J Med Chem 56: 2294-310 (2013) Article DOI: 10.1021/jm301619u BindingDB Entry DOI: 10.7270/Q21837VX
Merck& Co., Inc. Curated by ChEMBL					More data for this Ligand-Target Pair