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BDBM50427496 CHEMBL2322556

SMILES: Cc1c(CC(=O)NCc2ccccc2Cl)c(=O)oc2c(C)c3occ(c3cc12)C(C)(C)C

InChI Key: InChIKey=MQDYWACITIXNAK-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50427496   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50427496
PNG
(CHEMBL2322556)
Show SMILES Cc1c(CC(=O)NCc2ccccc2Cl)c(=O)oc2c(C)c3occ(c3cc12)C(C)(C)C
Show InChI InChI=1S/C26H26ClNO4/c1-14-17-10-19-20(26(3,4)5)13-31-23(19)15(2)24(17)32-25(30)18(14)11-22(29)28-12-16-8-6-7-9-21(16)27/h6-10,13H,11-12H2,1-5H3,(H,28,29)
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PC sid
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Article
PubMed
n/an/an/an/a 5.00E+6n/an/an/an/a



Universit£ degli Studi di Padova

Curated by ChEMBL


Assay Description
Inhibition of human NF-kappaB p50/DNA interaction using 32P-labeled oligonucleotides as substrate preincubated for 20 mins before substrate addition ...


J Med Chem 56: 1830-42 (2013)


Article DOI: 10.1021/jm3009647
BindingDB Entry DOI: 10.7270/Q2TH8P10
More data for this
Ligand-Target Pair