BDBM50428716 CHEMBL2333128::US9884828, 2-41
SMILES: C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O)C1CC1
InChI Key: InChIKey=HAZVCDSGCISCHC-GFCCVEGCSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human)) | BDBM50428716 (CHEMBL2333128 | US9884828, 2-41) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphory... | Bioorg Med Chem Lett 23: 71-4 (2012) Article DOI: 10.1016/j.bmcl.2012.11.021 BindingDB Entry DOI: 10.7270/Q2930VHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human)) | BDBM50428716 (CHEMBL2333128 | US9884828, 2-41) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <6 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Imago Pharmaceuticals, Inc. US Patent | Assay Description Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v... | US Patent US9884828 (2018) BindingDB Entry DOI: 10.7270/Q2NG4SNW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony stimulating factor receptor (Homo sapiens (Human)) | BDBM50428716 (CHEMBL2333128 | US9884828, 2-41) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of CSF1R (unknown origin) by TR-FRET assay in presence of ATP | Bioorg Med Chem Lett 23: 71-4 (2012) Article DOI: 10.1016/j.bmcl.2012.11.021 BindingDB Entry DOI: 10.7270/Q2930VHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM50428716 (CHEMBL2333128 | US9884828, 2-41) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of PDGFRalpha (unknown origin) by TR-FRET assay in presence of ATP | Bioorg Med Chem Lett 23: 71-4 (2012) Article DOI: 10.1016/j.bmcl.2012.11.021 BindingDB Entry DOI: 10.7270/Q2930VHH | |||||||||||
More data for this Ligand-Target Pair |