BDBM50429775 CHEMBL2336353::N-(2-Hydroxyphenyl)Cinnamamide
SMILES: Oc1ccccc1NC(=O)\C=C\c1ccccc1
InChI Key: InChIKey=CYJJBQPBDGQQFZ-ZHACJKMWSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Shiga toxin subunit A (Shigella dysenteriae) | BDBM50429775 (CHEMBL2336353 | N-(2-Hydroxyphenyl)Cinnamamide) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.87E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b... | J Med Chem 59: 10763-10773 (2016) Article DOI: 10.1021/acs.jmedchem.6b01517 BindingDB Entry DOI: 10.7270/Q2571DZG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interstitial collagenase (Homo sapiens (Human)) | BDBM50429775 (CHEMBL2336353 | N-(2-Hydroxyphenyl)Cinnamamide) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University of Chinese Medicine Curated by ChEMBL | Assay Description Inhibition of human recombinant MMP1 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins | Bioorg Med Chem Lett 23: 1206-11 (2013) Article DOI: 10.1016/j.bmcl.2013.01.027 BindingDB Entry DOI: 10.7270/Q2H996JF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50429775 (CHEMBL2336353 | N-(2-Hydroxyphenyl)Cinnamamide) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University of Chinese Medicine Curated by ChEMBL | Assay Description Inhibition of human recombinant MMP2 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins | Bioorg Med Chem Lett 23: 1206-11 (2013) Article DOI: 10.1016/j.bmcl.2013.01.027 BindingDB Entry DOI: 10.7270/Q2H996JF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-9 (Homo sapiens (Human)) | BDBM50429775 (CHEMBL2336353 | N-(2-Hydroxyphenyl)Cinnamamide) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University of Chinese Medicine Curated by ChEMBL | Assay Description Inhibition of human recombinant MMP9 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins | Bioorg Med Chem Lett 23: 1206-11 (2013) Article DOI: 10.1016/j.bmcl.2013.01.027 BindingDB Entry DOI: 10.7270/Q2H996JF | |||||||||||
More data for this Ligand-Target Pair |