BDBM50430332 CHEMBL2334289

SMILES: O=c1[nH]c(nc2ccc(cc12)-c1ccncc1)[C@@H]1CNC[C@H]1c1ccccc1

InChI Key: InChIKey=NKKOAZFGRRTXCV-VQTJNVASSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50430332   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50430332 (CHEMBL2334289) Show SMILES O=c1[nH]c(nc2ccc(cc12)-c1ccncc1)[C@@H]1CNC[C@H]1c1ccccc1 |r| Show InChI InChI=1S/C23H20N4O/c28-23-18-12-17(15-8-10-24-11-9-15)6-7-21(18)26-22(27-23)20-14-25-13-19(20)16-4-2-1-3-5-16/h1-12,19-20,25H,13-14H2,(H,26,27,28)/t19-,20+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Translational Research Institute Curated by ChEMBL					Assay Description Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...				Bioorg Med Chem Lett 23: 1592-9 (2013) Article DOI: 10.1016/j.bmcl.2013.01.109 BindingDB Entry DOI: 10.7270/Q2TD9ZQM
					More data for this Ligand-Target Pair