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SMILES: COc1ccc(cc1)C(N)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1C

InChI Key: InChIKey=AATRABILWFVXRE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50430334   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM50430334
PNG
(CHEMBL2334287)
Show SMILES COc1ccc(cc1)C(N)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1C
Show InChI InChI=1S/C20H19N5O2/c1-11-16(10-22-25-11)13-5-8-17-15(9-13)20(26)24-19(23-17)18(21)12-3-6-14(27-2)7-4-12/h3-10,18H,21H2,1-2H3,(H,22,25)(H,23,24,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
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UniChem

Similars
Article
PubMed
n/an/a 98n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...

Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
BindingDB Entry DOI: 10.7270/Q2TD9ZQM
More data for this
Ligand-Target Pair