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SMILES: CN(C)c1nc(nc2ccc(cc12)-c1cn[nH]c1)[C@@H](N)Cc1cccc(F)c1

InChI Key: InChIKey=WISDSCBNPFMRSU-SFHVURJKSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50430340   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM50430340
PNG
(CHEMBL2333892)
Show SMILES CN(C)c1nc(nc2ccc(cc12)-c1cn[nH]c1)[C@@H](N)Cc1cccc(F)c1 |r|
Show InChI InChI=1S/C21H21FN6/c1-28(2)21-17-10-14(15-11-24-25-12-15)6-7-19(17)26-20(27-21)18(23)9-13-4-3-5-16(22)8-13/h3-8,10-12,18H,9,23H2,1-2H3,(H,24,25)/t18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem

Similars
Article
PubMed
n/an/a 67n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...

Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
BindingDB Entry DOI: 10.7270/Q2TD9ZQM
More data for this
Ligand-Target Pair