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SMILES: CN(C)Cc1c(O)c2cc(Cl)ccc2nc1-c1ccccc1

InChI Key: InChIKey=WJKFJLKNXBRDQI-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50430825   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50430825
PNG
(CHEMBL2335134)
Show SMILES CN(C)Cc1c(O)c2cc(Cl)ccc2nc1-c1ccccc1
Show InChI InChI=1S/C18H17ClN2O/c1-21(2)11-15-17(12-6-4-3-5-7-12)20-16-9-8-13(19)10-14(16)18(15)22/h3-10H,11H2,1-2H3,(H,20,22)
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PC cid
PC sid
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Article
PubMed
n/an/an/a 1.02E+5n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Binding affinity to human PDE10A catalytic domain expressed in Escherichia coli BL21-Gold(DE3) after 15 mins by SPR inhibition in solution assay

J Med Chem 56: 3228-34 (2013)


Article DOI: 10.1021/jm301665y
BindingDB Entry DOI: 10.7270/Q2G1625N
More data for this
Ligand-Target Pair