BDBM50430982 CHEMBL2337863
SMILES: Oc1cccn(Cc2cn(nn2)-c2ccccc2)c1=S
InChI Key: InChIKey=SKRDXBWAVNFLCE-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM50430982 (CHEMBL2337863) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.57E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Georgia Tech Research Corporation US Patent | Assay Description Fluor de Lys is a fluorescence based HDAC activity assay comprising a combination of fluorogenic Histone deAcetylase Lysyl substrate and a developer.... | US Patent US8871728 (2014) BindingDB Entry DOI: 10.7270/Q29885R4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM50430982 (CHEMBL2337863) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia Institute of Technology Curated by ChEMBL | Assay Description Inhibition of HDAC8 catalytic domain (unknown origin) expressed in Escherichia coli BL21 (DE3) using GRKacFGC as substrate after 60 mins by SAMDI mas... | J Med Chem 56: 9969-81 (2013) Article DOI: 10.1021/jm401225q BindingDB Entry DOI: 10.7270/Q2W95D4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM50430982 (CHEMBL2337863) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia Institute of Technology Curated by ChEMBL | Assay Description Inhibition of HDAC8 (unknown origin) after 60 mins by SAMDI spectrophotometric analysis | J Med Chem 56: 3492-506 (2013) Article DOI: 10.1021/jm301769u BindingDB Entry DOI: 10.7270/Q29C6ZSC | |||||||||||
More data for this Ligand-Target Pair |