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SMILES: CCOc1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1

InChI Key: InChIKey=GWFMJOSUQIGWBN-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50432962   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50432962
PNG
(CHEMBL2375385)
Show SMILES CCOc1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1
Show InChI InChI=1S/C31H36N4O3S/c1-2-38-26-13-14-28-29(23-26)39-30(32-28)33-31(36)35(18-17-34-19-21-37-22-20-34)16-15-27(24-9-5-3-6-10-24)25-11-7-4-8-12-25/h3-14,23,27H,2,15-22H2,1H3,(H,32,33,36)
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Article
PubMed
n/an/an/an/a 1.00E+3n/an/an/an/a



Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...

Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
BindingDB Entry DOI: 10.7270/Q228090Q
More data for this
Ligand-Target Pair