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SMILES: Clc1cccc2sc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)nc12

InChI Key: InChIKey=SBRNTRWUMVKRJA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50432976   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50432976
PNG
(CHEMBL2377740)
Show SMILES Clc1cccc2sc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)nc12
Show InChI InChI=1S/C29H31ClN4O2S/c30-25-12-7-13-26-27(25)31-28(37-26)32-29(35)34(17-16-33-18-20-36-21-19-33)15-14-24(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,24H,14-21H2,(H,31,32,35)
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n/an/an/an/a 20n/an/an/an/a



Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...

Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
BindingDB Entry DOI: 10.7270/Q228090Q
More data for this
Ligand-Target Pair