null

SMILES: COc1ncc(cc1F)-c1cc2c(C)nc(N)nc2n([C@@H]2CC[C@@H](CC2)OCO)c1=O

InChI Key: InChIKey=SAQMYGKYGQDHJG-OKILXGFUSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50433031   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Mus musculus (Mouse))	BDBM50433031 (CHEMBL2376094) Show SMILES COc1ncc(cc1F)-c1cc2c(C)nc(N)nc2n([C@@H]2CC[C@@H](CC2)OCO)c1=O |r,wD:20.21,23.28,(38.17,-2.19,;36.84,-1.42,;35.5,-2.19,;35.5,-3.73,;34.16,-4.49,;32.83,-3.72,;32.83,-2.18,;34.16,-1.41,;34.16,.14,;31.49,-4.48,;30.15,-3.69,;28.81,-4.47,;27.47,-3.71,;27.47,-2.17,;26.14,-4.48,;26.14,-6.02,;24.81,-6.79,;27.48,-6.79,;28.8,-6.03,;30.14,-6.8,;30.13,-8.34,;31.46,-9.11,;31.45,-10.65,;30.11,-11.42,;28.79,-10.63,;28.8,-9.1,;30.1,-12.95,;28.77,-13.72,;27.44,-12.94,;31.49,-6.03,;32.82,-6.8,)| Show InChI InChI=1S/C21H24FN5O4/c1-11-15-8-16(12-7-17(22)19(30-2)24-9-12)20(29)27(18(15)26-21(23)25-11)13-3-5-14(6-4-13)31-10-28/h7-9,13-14,28H,3-6,10H2,1-2H3,(H2,23,25,26)/t13-,14+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of mouse PI3Kalpha				Bioorg Med Chem Lett 23: 2787-92 (2013) Article DOI: 10.1016/j.bmcl.2013.02.020 BindingDB Entry DOI: 10.7270/Q2NZ890X
					More data for this Ligand-Target Pair