Found 4 hits for monomerid = 50433041 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3K alpha)
(Mus musculus (Mouse)) | BDBM50433041
(CHEMBL2375960 | US8633204, 306)Show SMILES Cc1nc(N)nc2n([C@@H]3CC[C@@H](CC3)OCC(N)=O)c(=O)c(cc12)-c1cnn(C)c1 |r,wD:8.7,11.14,(54.57,-30.85,;54.57,-32.39,;53.24,-33.16,;53.24,-34.71,;51.91,-35.48,;54.58,-35.48,;55.9,-34.71,;57.24,-35.49,;57.24,-37.03,;58.57,-37.79,;58.56,-39.34,;57.22,-40.1,;55.89,-39.32,;55.9,-37.79,;57.21,-41.64,;55.87,-42.4,;54.54,-41.63,;53.2,-42.39,;54.55,-40.09,;58.59,-34.72,;59.92,-35.49,;58.59,-33.16,;57.25,-32.38,;55.91,-33.16,;59.93,-32.4,;61.32,-33.04,;62.36,-31.91,;61.61,-30.57,;62.24,-29.17,;60.1,-30.88,)| Show InChI InChI=1S/C20H25N7O3/c1-11-15-7-16(12-8-23-26(2)9-12)19(29)27(18(15)25-20(22)24-11)13-3-5-14(6-4-13)30-10-17(21)28/h7-9,13-14H,3-6,10H2,1-2H3,(H2,21,28)(H2,22,24,25)/t13-,14+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of mouse PI3Kalpha |
Bioorg Med Chem Lett 23: 2787-92 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.020 BindingDB Entry DOI: 10.7270/Q2NZ890X |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50433041
(CHEMBL2375960 | US8633204, 306)Show SMILES Cc1nc(N)nc2n([C@@H]3CC[C@@H](CC3)OCC(N)=O)c(=O)c(cc12)-c1cnn(C)c1 |r,wD:8.7,11.14,(54.57,-30.85,;54.57,-32.39,;53.24,-33.16,;53.24,-34.71,;51.91,-35.48,;54.58,-35.48,;55.9,-34.71,;57.24,-35.49,;57.24,-37.03,;58.57,-37.79,;58.56,-39.34,;57.22,-40.1,;55.89,-39.32,;55.9,-37.79,;57.21,-41.64,;55.87,-42.4,;54.54,-41.63,;53.2,-42.39,;54.55,-40.09,;58.59,-34.72,;59.92,-35.49,;58.59,-33.16,;57.25,-32.38,;55.91,-33.16,;59.93,-32.4,;61.32,-33.04,;62.36,-31.91,;61.61,-30.57,;62.24,-29.17,;60.1,-30.88,)| Show InChI InChI=1S/C20H25N7O3/c1-11-15-7-16(12-8-23-26(2)9-12)19(29)27(18(15)25-20(22)24-11)13-3-5-14(6-4-13)30-10-17(21)28/h7-9,13-14H,3-6,10H2,1-2H3,(H2,21,28)(H2,22,24,25)/t13-,14+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 93 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of mTOR (unknown origin) |
Bioorg Med Chem Lett 23: 2787-92 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.020 BindingDB Entry DOI: 10.7270/Q2NZ890X |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50433041
(CHEMBL2375960 | US8633204, 306)Show SMILES Cc1nc(N)nc2n([C@@H]3CC[C@@H](CC3)OCC(N)=O)c(=O)c(cc12)-c1cnn(C)c1 |r,wD:8.7,11.14,(54.57,-30.85,;54.57,-32.39,;53.24,-33.16,;53.24,-34.71,;51.91,-35.48,;54.58,-35.48,;55.9,-34.71,;57.24,-35.49,;57.24,-37.03,;58.57,-37.79,;58.56,-39.34,;57.22,-40.1,;55.89,-39.32,;55.9,-37.79,;57.21,-41.64,;55.87,-42.4,;54.54,-41.63,;53.2,-42.39,;54.55,-40.09,;58.59,-34.72,;59.92,-35.49,;58.59,-33.16,;57.25,-32.38,;55.91,-33.16,;59.93,-32.4,;61.32,-33.04,;62.36,-31.91,;61.61,-30.57,;62.24,-29.17,;60.1,-30.88,)| Show InChI InChI=1S/C20H25N7O3/c1-11-15-7-16(12-8-23-26(2)9-12)19(29)27(18(15)25-20(22)24-11)13-3-5-14(6-4-13)30-10-17(21)28/h7-9,13-14H,3-6,10H2,1-2H3,(H2,21,28)(H2,22,24,25)/t13-,14+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 58.1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer Inc.
US Patent
| Assay Description Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in... |
US Patent US8633204 (2014)
BindingDB Entry DOI: 10.7270/Q2Q81BQT |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50433041
(CHEMBL2375960 | US8633204, 306)Show SMILES Cc1nc(N)nc2n([C@@H]3CC[C@@H](CC3)OCC(N)=O)c(=O)c(cc12)-c1cnn(C)c1 |r,wD:8.7,11.14,(54.57,-30.85,;54.57,-32.39,;53.24,-33.16,;53.24,-34.71,;51.91,-35.48,;54.58,-35.48,;55.9,-34.71,;57.24,-35.49,;57.24,-37.03,;58.57,-37.79,;58.56,-39.34,;57.22,-40.1,;55.89,-39.32,;55.9,-37.79,;57.21,-41.64,;55.87,-42.4,;54.54,-41.63,;53.2,-42.39,;54.55,-40.09,;58.59,-34.72,;59.92,-35.49,;58.59,-33.16,;57.25,-32.38,;55.91,-33.16,;59.93,-32.4,;61.32,-33.04,;62.36,-31.91,;61.61,-30.57,;62.24,-29.17,;60.1,-30.88,)| Show InChI InChI=1S/C20H25N7O3/c1-11-15-7-16(12-8-23-26(2)9-12)19(29)27(18(15)25-20(22)24-11)13-3-5-14(6-4-13)30-10-17(21)28/h7-9,13-14H,3-6,10H2,1-2H3,(H2,21,28)(H2,22,24,25)/t13-,14+ | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 988 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of AKT phosphorylation at Ser 473 in human BT20 cells |
Bioorg Med Chem Lett 23: 2787-92 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.020 BindingDB Entry DOI: 10.7270/Q2NZ890X |
More data for this Ligand-Target Pair | |