BDBM50433389 CHEMBL2375618

SMILES: CCOC(=O)COc1ccc(cc1)N1CCN(CC1)c1cc(nc2ccccc12)-c1ccccn1

InChI Key: InChIKey=IOCJYWLSXRUGLP-UHFFFAOYSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50433389   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Methionine Aminopeptidase Type 1 (MetAP1) (Homo sapiens (Human))	BDBM50433389 (CHEMBL2375618) Show SMILES CCOC(=O)COc1ccc(cc1)N1CCN(CC1)c1cc(nc2ccccc12)-c1ccccn1 Show InChI InChI=1S/C28H28N4O3/c1-2-34-28(33)20-35-22-12-10-21(11-13-22)31-15-17-32(18-16-31)27-19-26(25-9-5-6-14-29-25)30-24-8-4-3-7-23(24)27/h3-14,19H,2,15-18,20H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
Johns Hopkins University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human methionine aminopeptidase 1 in presence of Co2+				J Med Chem 56: 3996-4016 (2013) Article DOI: 10.1021/jm400227z BindingDB Entry DOI: 10.7270/Q2SJ1N1Z
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM50433389 (CHEMBL2375618) Show SMILES CCOC(=O)COc1ccc(cc1)N1CCN(CC1)c1cc(nc2ccccc12)-c1ccccn1 Show InChI InChI=1S/C28H28N4O3/c1-2-34-28(33)20-35-22-12-10-21(11-13-22)31-15-17-32(18-16-31)27-19-26(25-9-5-6-14-29-25)30-24-8-4-3-7-23(24)27/h3-14,19H,2,15-18,20H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Johns Hopkins University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human methionine aminopeptidase 2 in presence of Mn2+				J Med Chem 56: 3996-4016 (2013) Article DOI: 10.1021/jm400227z BindingDB Entry DOI: 10.7270/Q2SJ1N1Z
					More data for this Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1) (Homo sapiens (Human))	BDBM50433389 (CHEMBL2375618) Show SMILES CCOC(=O)COc1ccc(cc1)N1CCN(CC1)c1cc(nc2ccccc12)-c1ccccn1 Show InChI InChI=1S/C28H28N4O3/c1-2-34-28(33)20-35-22-12-10-21(11-13-22)31-15-17-32(18-16-31)27-19-26(25-9-5-6-14-29-25)30-24-8-4-3-7-23(24)27/h3-14,19H,2,15-18,20H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a
Johns Hopkins University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human methionine aminopeptidase 1 in presence of Mn2+				J Med Chem 56: 3996-4016 (2013) Article DOI: 10.1021/jm400227z BindingDB Entry DOI: 10.7270/Q2SJ1N1Z
					More data for this Ligand-Target Pair