Found 5 hits for monomerid = 50433549 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50433549
(CHEMBL2381266)Show SMILES CC(C)n1ncnc1-c1nc-2c(CCOc3cc(ccc-23)C2CCNC2)s1 Show InChI InChI=1S/C20H23N5OS/c1-12(2)25-19(22-11-23-25)20-24-18-15-4-3-13(14-5-7-21-10-14)9-16(15)26-8-6-17(18)27-20/h3-4,9,11-12,14,21H,5-8,10H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GST-fused human recombinant PI3Kalpha expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presen... |
Bioorg Med Chem Lett 23: 2606-13 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.102 BindingDB Entry DOI: 10.7270/Q2W95BKF |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50433549
(CHEMBL2381266)Show SMILES CC(C)n1ncnc1-c1nc-2c(CCOc3cc(ccc-23)C2CCNC2)s1 Show InChI InChI=1S/C20H23N5OS/c1-12(2)25-19(22-11-23-25)20-24-18-15-4-3-13(14-5-7-21-10-14)9-16(15)26-8-6-17(18)27-20/h3-4,9,11-12,14,21H,5-8,10H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc.
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha in human PC3 cells assessed as inhibition of AKT phosphorylation at Ser473 after 2 hrs by ELISA |
Bioorg Med Chem Lett 23: 2606-13 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.102 BindingDB Entry DOI: 10.7270/Q2W95BKF |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50433549
(CHEMBL2381266)Show SMILES CC(C)n1ncnc1-c1nc-2c(CCOc3cc(ccc-23)C2CCNC2)s1 Show InChI InChI=1S/C20H23N5OS/c1-12(2)25-19(22-11-23-25)20-24-18-15-4-3-13(14-5-7-21-10-14)9-16(15)26-8-6-17(18)27-20/h3-4,9,11-12,14,21H,5-8,10H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GST-fused human recombinant PI3Kdelta expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presen... |
Bioorg Med Chem Lett 23: 2606-13 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.102 BindingDB Entry DOI: 10.7270/Q2W95BKF |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50433549
(CHEMBL2381266)Show SMILES CC(C)n1ncnc1-c1nc-2c(CCOc3cc(ccc-23)C2CCNC2)s1 Show InChI InChI=1S/C20H23N5OS/c1-12(2)25-19(22-11-23-25)20-24-18-15-4-3-13(14-5-7-21-10-14)9-16(15)26-8-6-17(18)27-20/h3-4,9,11-12,14,21H,5-8,10H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GST-fused human recombinant PI3Kgamma expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presen... |
Bioorg Med Chem Lett 23: 2606-13 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.102 BindingDB Entry DOI: 10.7270/Q2W95BKF |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50433549
(CHEMBL2381266)Show SMILES CC(C)n1ncnc1-c1nc-2c(CCOc3cc(ccc-23)C2CCNC2)s1 Show InChI InChI=1S/C20H23N5OS/c1-12(2)25-19(22-11-23-25)20-24-18-15-4-3-13(14-5-7-21-10-14)9-16(15)26-8-6-17(18)27-20/h3-4,9,11-12,14,21H,5-8,10H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GST-fused human recombinant PI3Kbeta expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presenc... |
Bioorg Med Chem Lett 23: 2606-13 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.102 BindingDB Entry DOI: 10.7270/Q2W95BKF |
More data for this Ligand-Target Pair | |