BDBM50433607 CHEMBL2381985

SMILES: C[C@H](Nc1cc(nc(Nc2cc(C)n[nH]2)n1)N1CCOCC1)c1ncc(F)cn1

InChI Key: InChIKey=FSGWUHMHSBTDLW-LBPRGKRZSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50433607   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50433607 (CHEMBL2381985) Show SMILES C[C@H](Nc1cc(nc(Nc2cc(C)n[nH]2)n1)N1CCOCC1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C18H22FN9O/c1-11-7-15(27-26-11)24-18-23-14(8-16(25-18)28-3-5-29-6-4-28)22-12(2)17-20-9-13(19)10-21-17/h7-10,12H,3-6H2,1-2H3,(H3,22,23,24,25,26,27)/t12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin) using biotinylated TYK2 peptide as substrate after 60 mins				Bioorg Med Chem Lett 23: 3105-10 (2013) Article DOI: 10.1016/j.bmcl.2013.02.111 BindingDB Entry DOI: 10.7270/Q23T9JMX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50433607 (CHEMBL2381985) Show SMILES C[C@H](Nc1cc(nc(Nc2cc(C)n[nH]2)n1)N1CCOCC1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C18H22FN9O/c1-11-7-15(27-26-11)24-18-23-14(8-16(25-18)28-3-5-29-6-4-28)22-12(2)17-20-9-13(19)10-21-17/h7-10,12H,3-6H2,1-2H3,(H3,22,23,24,25,26,27)/t12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of JAK3 (unknown origin) using biotinylated poly-EY peptide as substrate after 60 mins by HTRF assay				Bioorg Med Chem Lett 23: 3105-10 (2013) Article DOI: 10.1016/j.bmcl.2013.02.111 BindingDB Entry DOI: 10.7270/Q23T9JMX
					More data for this Ligand-Target Pair