BDBM50434069 CHEMBL2381339::US9676792, Compound 24
SMILES: COc1cc(ccc1Nc1ncc2N(C)C(=O)c3cccc4CCN(c34)c2n1)C(=O)N1CCC(CC1)N1CCN(C)CC1
InChI Key: InChIKey=UWHQAHZPBAISBU-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Extracellular signal-regulated kinase 5 (ERK5) (Homo sapiens (Human)) | BDBM50434069 (CHEMBL2381339 | US9676792, Compound 24) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
University of Oxford Curated by ChEMBL | Assay Description Inhibition of GST-tagged full length human ERK5 transfected in HEK293 cells assessed as inhibition of AP1 transcriptional activity after 24 hrs by du... | J Med Chem 56: 4413-21 (2013) Article DOI: 10.1021/jm4000837 BindingDB Entry DOI: 10.7270/Q2RF5WDZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular signal-regulated kinase 5 (ERK5) (Homo sapiens (Human)) | BDBM50434069 (CHEMBL2381339 | US9676792, Compound 24) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 199 | n/a | 260 | n/a | n/a | 7.5 | n/a |
Dana-Farber Cancer Institute, Inc. US Patent | Assay Description Kinase activity was determined in an assay volume of 40 μl in kinase buffer (50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 1 mM 2-mercaptoethanol) contai... | US Patent US9676792 (2017) BindingDB Entry DOI: 10.7270/Q2Z31WT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S (Homo sapiens (Human)) | BDBM50434069 (CHEMBL2381339 | US9676792, Compound 24) | PDB GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc. US Patent | Assay Description In vitro kinase assays were conducted at Invitrogen (Madison, Wis.) using the SelectScreen Kinase Profiling Service. | US Patent US9676792 (2017) BindingDB Entry DOI: 10.7270/Q2Z31WT7 | |||||||||||
More data for this Ligand-Target Pair |