BDBM50434763 CHEMBL2385817
SMILES: CC(C)C[C@H](NC(=O)Cn1ccc2ncccc2c1=O)B(O)O
InChI Key: InChIKey=YVMYATWMIRGYBP-ZDUSSCGKSA-N
Data: 5 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
20S proteasome chymotrypsin-like (Homo sapiens (Human)) | BDBM50434763 (CHEMBL2385817) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Messina Curated by ChEMBL | Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit assessed as Suc-Leu-Leu-Val-Tyr-AMC substrate hydrolysis after 10 min... | Eur J Med Chem 76: 1-9 (2014) Article DOI: 10.1016/j.ejmech.2014.01.022 BindingDB Entry DOI: 10.7270/Q23N24XM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
20S proteasome chymotrypsin-like (Homo sapiens (Human)) | BDBM50434763 (CHEMBL2385817) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Messina Curated by ChEMBL | Assay Description Inhibition of chymotrypsin-like activity of 20S proteasome in human erythrocytes using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence assay | Eur J Med Chem 83: 1-14 (2014) Article DOI: 10.1016/j.ejmech.2014.06.017 BindingDB Entry DOI: 10.7270/Q2DZ09WC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
20S proteasome chymotrypsin-like (Homo sapiens (Human)) | BDBM50434763 (CHEMBL2385817) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Messina Curated by ChEMBL | Assay Description Inhibition of human 20S proteasome chymotrypsin like activity using Suc-Leu-Leu-Val-Tyr-AMC as substrate measured over 10 mins by fluorescence assay | Eur J Med Chem 64: 23-34 (2013) Article DOI: 10.1016/j.ejmech.2013.03.032 BindingDB Entry DOI: 10.7270/Q2S46TC8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome component C5 (Homo sapiens (Human)) | BDBM50434763 (CHEMBL2385817) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Messina Curated by ChEMBL | Assay Description Inhibition of human 20S proteasome post-glutamyl peptide hydrolyzing activity using Z-Leu-Leu-Glu-AMC as substrate measured over 10 mins by fluoresce... | Eur J Med Chem 64: 23-34 (2013) Article DOI: 10.1016/j.ejmech.2013.03.032 BindingDB Entry DOI: 10.7270/Q2S46TC8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome component C5 (Homo sapiens (Human)) | BDBM50434763 (CHEMBL2385817) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Messina Curated by ChEMBL | Assay Description Inhibition of PGPH-like activity of 20S proteasome in human erythrocytes using Z-Leu-Leu-Glu-AMC as substrate by fluorescence assay | Eur J Med Chem 83: 1-14 (2014) Article DOI: 10.1016/j.ejmech.2014.06.017 BindingDB Entry DOI: 10.7270/Q2DZ09WC | |||||||||||
More data for this Ligand-Target Pair |