Found 4 hits for monomerid = 50435519 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50435519
(CHEMBL2392493)Show SMILES CC1(CCN(CC1)S(C)(=O)=O)n1nnc2cnc3[nH]ccc3c12 Show InChI InChI=1S/C14H18N6O2S/c1-14(4-7-19(8-5-14)23(2,21)22)20-12-10-3-6-15-13(10)16-9-11(12)17-18-20/h3,6,9H,4-5,7-8H2,1-2H3,(H,15,16) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of JAK1 (unknown origin) |
Bioorg Med Chem Lett 23: 3592-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.018
BindingDB Entry DOI: 10.7270/Q2GH9KB2 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50435519
(CHEMBL2392493)Show SMILES CC1(CCN(CC1)S(C)(=O)=O)n1nnc2cnc3[nH]ccc3c12 Show InChI InChI=1S/C14H18N6O2S/c1-14(4-7-19(8-5-14)23(2,21)22)20-12-10-3-6-15-13(10)16-9-11(12)17-18-20/h3,6,9H,4-5,7-8H2,1-2H3,(H,15,16) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of JAK2 (unknown origin) |
Bioorg Med Chem Lett 23: 3592-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.018
BindingDB Entry DOI: 10.7270/Q2GH9KB2 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50435519
(CHEMBL2392493)Show SMILES CC1(CCN(CC1)S(C)(=O)=O)n1nnc2cnc3[nH]ccc3c12 Show InChI InChI=1S/C14H18N6O2S/c1-14(4-7-19(8-5-14)23(2,21)22)20-12-10-3-6-15-13(10)16-9-11(12)17-18-20/h3,6,9H,4-5,7-8H2,1-2H3,(H,15,16) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 369 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of JAK3 (unknown origin) |
Bioorg Med Chem Lett 23: 3592-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.018
BindingDB Entry DOI: 10.7270/Q2GH9KB2 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50435519
(CHEMBL2392493)Show SMILES CC1(CCN(CC1)S(C)(=O)=O)n1nnc2cnc3[nH]ccc3c12 Show InChI InChI=1S/C14H18N6O2S/c1-14(4-7-19(8-5-14)23(2,21)22)20-12-10-3-6-15-13(10)16-9-11(12)17-18-20/h3,6,9H,4-5,7-8H2,1-2H3,(H,15,16) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 220 | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of JAK1-mediated STAT3 phosphorylation in IL6-induced human TF1 cells |
Bioorg Med Chem Lett 23: 3592-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.018
BindingDB Entry DOI: 10.7270/Q2GH9KB2 |
More data for this
Ligand-Target Pair | |
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